{"id":21332,"date":"2011-10-19T19:48:41","date_gmt":"2011-10-19T22:48:41","guid":{"rendered":"http:\/\/www.inclusive.org.br\/?p=21332"},"modified":"2011-10-19T19:48:41","modified_gmt":"2011-10-19T22:48:41","slug":"alternativa-para-alzheimer","status":"publish","type":"post","link":"https:\/\/inclusivenews.com.br\/?p=21332","title":{"rendered":"Alternativa para Alzheimer"},"content":{"rendered":"<figure style=\"width: 212px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\" \" title=\"Neur\u00f4nio\" src=\"http:\/\/2.bp.blogspot.com\/_PaeGFK5b1uQ\/TGO4RnWVHpI\/AAAAAAAAuMo\/bfePYcHTliA\/s640\/neuronio.jpg\" alt=\"\" width=\"212\" height=\"168\" \/><figcaption class=\"wp-caption-text\"> <\/figcaption><\/figure>\n<p>Uma pequena parte de um receptor cerebral acaba de ser anunciado por um grupo de cientistas nos Estados Unidos como um alvo promissor para o desenvolvimento de novos medicamentos contra Alzheimer e outras doen\u00e7as neurodegenerativas.<\/p>\n<p>A pesquisa sobre o receptor, um amino\u00e1cido denominado NMDA (N-metil-D-aspartato), foi feita na Universidade de Buffalo e teve seus resultados descritos em artigo publicado na ter\u00e7a-feira (11\/10) na <em>Nature Communications<\/em>.<\/p>\n<p>\u201c\u00c9 a primeira vez que essa regi\u00e3o do c\u00e9rebro se mostrou \u00fatil como um alvo de drogas. Se pudermos encontrar um composto qu\u00edmico que se ligue nessa regi\u00e3o e prenda as subunidades dos receptores NMDA, o resultado ser\u00e1 muito importante na busca de alternativas de tratamentos para danos provocados por acidentes vasculares cerebrais (AVC), Alzheimer e outras doen\u00e7as neurodegenerativas\u201d, disse Gabriela Popescu, principal autora do estudo.<\/p>\n<p>A pesquisa foi focada nos receptores cerebrais para o neurotransmissor glutamato, que est\u00e1 envolvido com tais doen\u00e7as bem como outras condi\u00e7\u00f5es, como o glaucoma.<\/p>\n<p>Os dois principais receptores no c\u00e9rebro para o glutamato s\u00e3o o NMDA e o AMPA, ambos com pap\u00e9is fundamentais na mem\u00f3ria e no aprendizado humano. Os dois s\u00e3o compostos de quatro subunidades, sendo que dentro de cada receptor essas subunidades s\u00e3o organizadas em pares.<\/p>\n<p>Como os dois receptores t\u00eam estruturas semelhantes, os cientistas estimavam que eles funcionassem de modo parecido. \u201cMas quando alteramos a interface de seus pares \u2013 o local em que as duas subunidades se agrupam com cada par \u2013, verificamos que o NMDA funciona da maneira oposta do AMPA\u201d, contou Popescu.<\/p>\n<p>Ao travar as duas subunidades juntas, o grupo conseguiu obter uma redu\u00e7\u00e3o expressiva na atividade do NMDA e, consequentemente, uma diminui\u00e7\u00e3o na quantidade de c\u00e1lcio que entra os neur\u00f4nios em resposta ao glutamato.<\/p>\n<p>O excesso de c\u00e1lcio devido \u00e0 maior atividade de receptores NMDA \u00e9 o que eventualmente terminar\u00e1 por matar neur\u00f4nios, levando aos sintomas comuns que ocorrem ap\u00f3s um AVC ou doen\u00e7as neurodegenerativas.<\/p>\n<p>A droga Namenda, um dos medicamentos atuais que atuam no receptor NMDA, tem como alvo um local diferente dentro do receptor daquele pesquisado pelo grupo da Universidade de Buffalo. Os pesquisadores esperam que o novo alvo possa resultar no desenvolvimento de drogas mais eficientes.<\/p>\n<p>O artigo <em>NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers<\/em> (doi:10.1038\/ncomms151), de Popespcu e outros, pode ser lido por assinantes da <em>Nature Communications<\/em> em <strong><a href=\"http:\/\/www.nature.com\/ncomms\" target=\"_blank\" rel=\"noopener\">www.nature.com\/ncomms<\/a><\/strong>.<\/p>\n<p>Fonte: <a href=\"http:\/\/agencia.fapesp.br\/14623\">Ag\u00eancia FAPESP<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Uma pequena parte de um receptor cerebral acaba de ser anunciado por um grupo de cientistas nos Estados Unidos como um alvo promissor para o desenvolvimento de novos medicamentos contra Alzheimer e outras doen\u00e7as neurodegenerativas. Da Ag\u00eancia Fapesp.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-container-style":"default","site-container-layout":"default","site-sidebar-layout":"default","disable-article-header":"default","disable-site-header":"default","disable-site-footer":"default","disable-content-area-spacing":"default","footnotes":""},"categories":[4,37],"tags":[],"class_list":["post-21332","post","type-post","status-publish","format-standard","hentry","category-noticias","category-saude"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alternativa para Alzheimer -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inclusivenews.com.br\/?p=21332\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alternativa para Alzheimer -\" \/>\n<meta property=\"og:description\" content=\"Uma pequena parte de um receptor cerebral acaba de ser anunciado por um grupo de cientistas nos Estados Unidos como um alvo promissor para o desenvolvimento de novos medicamentos contra Alzheimer e outras doen\u00e7as neurodegenerativas. 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